Insulin resistance and sustained virological response in hepatitis C: from bench to bedside
نویسندگان
چکیده
منابع مشابه
Hepatitis C reinfection after sustained virological response.
BACKGROUND & AIMS On-going risk behaviour can lead to hepatitis C virus (HCV) reinfection following successful treatment. We aimed to assess the incidence of persistent HCV reinfection in a population of people who inject drugs (PWID) who had achieved sustained virological response (SVR) seven years earlier. METHODS In 2004-2006 we conducted a multicentre treatment trial comprising HCV genoty...
متن کاملMeta-analysis: impact of sustained virological response on insulin resistance during hepatitis C therapy
Aim: Previous studies have shown that sustained virological response to standard chronic hepatitis C therapy appears to be associated with insulin resistance, however, the discrete relationship remains controversial. This meta-analysis was designed to evaluate whether the achievement of sustained virological response interfered with insulin resistance in chronic hepatitis C patients undergoing ...
متن کاملInterferon-γ-inducible protein-10 in chronic hepatitis C: Correlations with insulin resistance, histological features & sustained virological response
BACKGROUND & OBJECTIVES One of the multiple factors contributing to virological response in chronic hepatitis C (CHC) is interferon-gamma-inducible protein-10 (IP-10). Its level reflects the status of interferon-stimulated genes, which in turn is associated with virological response to antiviral therapy. The aim of this study was to evaluate the role of serum IP-10 levels on sustained virologic...
متن کاملHepatitis C virus reinfection among prisoners with sustained virological response after treatment for chronic hepatitis C.
BACKGROUND & AIMS We estimated HCV reinfection rate and its associated risk factors in inmates with chronic hepatitis C who had achieved sustained virological response (SVR) after completing combination therapy while in prison. METHODS Individuals who had achieved an SVR after treatment provided from January 2003 to December 2009 at four prisons in Catalonia, had been tested annually for HCV ...
متن کاملGlutaminolysis and insulin secretion: from bedside to bench and back.
Identification of regulatory mutations of glutamate dehydrogenase (GDH) in a form of congenital hyperinsulinism (GDH-HI) is providing a model for basal insulin secretion (IS) and amino acid (AA)-stimulated insulin secretion (AASIS) in which glutaminolysis plays a key role. Leucine and ADP are activators and GTP is an inhibitor of GDH. GDH-HI mutations impair GDH sensitivity to GTP inhibition, l...
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ژورنال
عنوان ژورنال: Liver International
سال: 2010
ISSN: 1478-3223
DOI: 10.1111/j.1478-3231.2010.02365.x